Some cleavage of lamin b may occur in the absence of caspase 3 whereas parp 1 another nuclear protein seems to be cleaved regardless of caspase 3. Activation of casp6 was upstream of casp3 7 activation and its inhibition was sufficient to prevent cell death in our system. Caspase 9 belongs to a family of caspases cysteine aspartic proteases involved in apoptosis and cytokine.
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